Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates.

نویسندگان

  • Deanna J Buehrle
  • Ryan K Shields
  • Liang Chen
  • Binghua Hao
  • Ellen G Press
  • Ammar Alkrouk
  • Brian A Potoski
  • Barry N Kreiswirth
  • Cornelius J Clancy
  • M Hong Nguyen
چکیده

We compared ceftazidime-avibactam, ceftolozane-tazobactam, ceftazidime, cefepime, and piperacillin-tazobactam MICs for 38 meropenem-resistant Pseudomonas aeruginosa isolates. No isolates harbored carbapenemases; 74% were oprD mutants. Ceftazidime-avibactam and ceftolozane-tazobactam were active against 92% of the isolates, including 80% that were resistant to all three β-lactams. Forty-three percent of ceftazidime-avibactam-susceptible isolates and 6% of ceftolozane-tazobactam-susceptible isolates exhibited MICs at the respective breakpoints. Ceftolozane-tazobactam and ceftazidime-avibactam are therapeutic options for meropenem-resistant P. aeruginosa infections that should be used judiciously to preserve activity.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 60 5  شماره 

صفحات  -

تاریخ انتشار 2016